C-terminal Propeptide of Type-I Procollagen as a Possible Biochemical Marker for Preclinical Detection of Cardiac Disease in Chronic Renal Failure
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چکیده
منابع مشابه
Procollagen type I carboxy-terminal propeptide as a marker of osteoblastic bone metastases.
Collagen type I is the sole collagen type found in bones and tendons. Carboxyterminal propeptide, deriving and cleaved from procollagen type I (PICP) during collagen synthesis, is delivered into the blood, where it can be measured. According to current knowledge, PICP correlates with bone collagen synthesis and bone formation rate. Elevated serum levels of PICP in patients with Paget's disease,...
متن کاملProcollagen Type I Carboxy-Terminal Propeptide as a Marker of Osteoblastic Bone Metastases1
Collagen type I is the sole collagen type found in bones and tendons. Carboxyterminal propeptide, deriving and cleaved from procollagen type I (PICP) during collagen synthesis, is delivered into the blood, where it can be measured. According to current knowledge, PICP correlates with bone collagen synthesis and bone formation rate. Elevated serum levels of PICP in patients with Paget’s disease,...
متن کاملEvolution of circulating C-terminal propeptide of type I procollagen in patients with chronic renal failure pre and post renal transplantation.
The carboxyterminal propeptide of type I procollagen is a biochemical marker of type I collagen synthesis. We evaluated circulating carboxyterminal propetide of type I procollagen levels in patients with terminal renal failure before and after kidney transplantation. Serum carboxyterminal propeptide of type I procollagen, osteocalcin, total alkaline phosphatase, intact parathyrin, creatinine, c...
متن کاملSerum carboxy-terminal propeptide of procollagen type I is a marker of myocardial fibrosis in hypertensive heart disease.
BACKGROUND This study was designed to investigate whether the serum concentration of the carboxy-terminal propeptide of procollagen type I (PIP), a marker of collagen type I synthesis, is related to myocardial fibrosis in hypertensive patients. METHODS AND RESULTS The study was performed in 26 patients with essential hypertension in which ischemic cardiomyopathy was excluded after a complete ...
متن کاملQuantitative Analysis of Serum Procollagen Type I C-Terminal Propeptide by Immunoassay on Microchip
BACKGROUND Sandwich enzyme-linked immunosorbent assay (ELISA) is one of the most frequently employed assays for clinical diagnosis, since this enables the investigator to identify specific protein biomarkers. However, the conventional assay using a 96-well microtitration plate is time- and sample-consuming, and therefore is not suitable for rapid diagnosis. To overcome these drawbacks, we perfo...
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ژورنال
عنوان ژورنال: Journal of Medical Sciences
سال: 2007
ISSN: 1682-4474
DOI: 10.3923/jms.2007.804.809